RESEARCH LETTERS
AIDS. 22(8):990-992, May 11, 2008.
Ndhlovu, Lishomwa C; Chapman, Joan M; Jha, Aashish R; Snyder-Cappione, Jennifer E; Pagan, Moraima ; Leal, Fabio E; Boland, Brigid S; Norris, Philip J; Rosenberg, Michael G; Nixon, Douglas F
Abstract:
IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.


